What is a serious consequence of septic shock that affects kidney function?

The serious consequence of septic shock that affects kidney function is hypotension leading to ischemia. In the context of septic shock, there is a systemic infection that causes widespread inflammation and vasodilation, resulting in a significant drop in blood pressure (hypotension). This low blood pressure can compromise blood flow to vital organs, including the kidneys, leading to reduced perfusion and oxygen supply (ischemia). When the kidneys do not receive adequate blood flow, their ability to filter waste and maintain fluid and electrolyte balance is impaired, which can lead to acute kidney injury or failure.

Although changes in heart rate, appetite, and blood pH may occur during septic shock, they do not directly relate to the immediate impact on kidney function in the way that hypotension and resultant ischemia do. The lack of sufficient blood flow and oxygen is what critically endangers the kidneys and can lead to long-term damage if not addressed promptly.